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Structure of 4837-22-3
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4-(Difluoromethylsulfonyl)benzoic acid features a strongly electron-withdrawing difluoromethylsulfonyl group that enhances acidity and metabolic stability. This aryl sulfone moiety integrates readily into bioactive molecules, offering improved solubility and resistance to oxidative degradation. The carboxylic acid functionality enables direct coupling reactions for conjugation in medicinal chemistry and materials science applications.
4-(Difluoromethylsulfonyl)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of a strongly electron-withdrawing difluoromethylsulfonyl group adjacent to a carboxylic acid. The molecule exhibits excellent bench stability and facilitates direct coupling reactions, including amide formation and esterification, with high functional group tolerance. Its ortho-directed reactivity profile supports efficient derivatization in late-stage functionalization strategies.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: