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CS-W001157 4
Total: USD 88.00

9-Phenanthrol

  • CAS No. 484-17-3

  • Cat. No. CS-0028825
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD00082298

*For research and further manufacturing use only, not for direct human use.

9-Phenanthrol|CS-0028825

Structure of 484-17-3

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General Information

  • CAS No. 484-17-3
  • Cat. No. CS-0028825
  • Purity ≥97%
  • MDL No. MFCD00082298
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₀O
  • Molecular Weight None
  • Synonym(s) 9-Hydroxyphenanthrene; NSC 50554
  • SMILES OC1=CC2=CC=CC=C2C3=CC=CC=C13

Application

9-Phenanthrol (CAS 484-17-3) inhibits the TRPM4 channel, a calcium-activated non-selective cation channel critical to cellular signaling and electrophysiological function. It blocks TRPM4 with high selectivity, achieving an IC50 of 20μM. Researchers leverage this inhibition to dissect TRPM4’s role in disease pathways and gene regulation networks. This setup streamlines functional genomics studies and offers a precise tool for probing channel-dependent gene expression.

Synthesis

  • Route1
    • null|null
      5085-74-5
    • ~92%
    • In-stock
      9-Phenanthrol|CS-0028825
      484-17-3

    References

    • Matsumoto, Jin; Ishizu, Masayuki; Kawano, Ryu-Ichiro; Hesaka, Daisuke; Shiragami, Tsutomu; Hayashi, Yoshimi; Yamashita, Toshiaki; Yasuda, Masahide Tetrahedron, 2005 , vol. 61, # 24 p. 5735 - 5740
  • Route2
    • In-stock
      Fluorenone|CS-0001481
      486-25-9
    • null|null
      18107-18-1
    • ~80%
    • In-stock
      9-Phenanthrol|CS-0028825
      484-17-3
    • null|null
      5085-74-5

    References

    • Hashimoto, Norio; Aoyama, Toyohiko; Shioiri, Takayuki Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 1 p. 119 - 124
  • Route3
    • null|null
      120270-41-9
    • ~96%
    • In-stock
      9-Phenanthrol|CS-0028825
      484-17-3

    References

    • Fu, Jian-Min; Snieckus, Victor Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   3.6986
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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