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CS-W001157 4
Total: USD 88.00

(S)-C4-TunePhos

  • CAS No. 486429-94-1

  • Cat. No. CS-0108779
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-C4-TunePhos|CS-0108779

Structure of 486429-94-1

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General Information

  • CAS No. 486429-94-1
  • Cat. No. CS-0108779
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₀H₃₄O₂P₂
  • Molecular Weight 608.64
  • Synonym(s) None
  • SMILES C12=CC=CC(P(C3=CC=CC=C3)C4=CC=CC=C4)=C1C5=C(C=CC=C5P(C6=CC=CC=C6)C7=CC=CC=C7)OCCCCO2

Description

(S)-C4-TunePhos is a chiral phosphine ligand designed for asymmetric catalysis, featuring a sterically tuned arylphosphine architecture that enhances enantioselectivity in palladium-catalyzed cross-coupling reactions. This bench-stable ligand integrates seamlessly into reaction systems requiring high stereocontrol and robust performance under standard conditions.

Application

(S)-C4-TunePhos serves as a highly effective chiral ligand in palladium-catalyzed cross-coupling reactions, enabling high enantioselectivity in the synthesis of biaryl and alkylated aryl building blocks. Its robust bench stability, broad functional group tolerance, and compatibility with standard reaction conditions make it ideal for iterative synthesis workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   7.4214
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   6

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