(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid

Name: (R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid
Brand: ChemScene
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CAS No. 486460-09-7
Cat. No. CS-0097838
Purity≥97%
MDL No.MFCD06659118

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(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid|CS-0097838

Structure of 486460-09-7

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Description

(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid is a chiral building block featuring a trifluorophenyl moiety and a protected amino group. This bench-stable, moisture-tolerant derivative enables direct incorporation into peptide synthesis workflows. The electron-deficient aryl ring enhances reactivity in coupling reactions, while the (R)-configuration ensures stereochemical fidelity in target molecule construction.

Application

(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of peptide-like scaffolds and bioactive molecules. The tert-butyl carbamate (Boc) group provides excellent stability and orthogonal deprotection under mild acidic conditions, while the 2,4,5-trifluorophenyl moiety enhances metabolic stability and modulates electronic properties. This compound facilitates efficient coupling reactions and is well-suited for solid-phase and solution-phase synthesis workflows.

General Information

CAS No. 486460-09-7
Cat. No. CS-0097838
Purity ≥97%
MDL No. MFCD06659118
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₆F₃NO₄
Molecular Weight 319.28
Synonym(s) boc-d-2,4,5-trifluorophenylalanine
SMILES O=C([C@@H](CC1=CC(F)=C(C=C1F)F)NC(OC(C)(C)C)=O)O

Computational Chemistry Data

TPSA 75.63
LogP 2.6243
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 4

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid

CAS No. 486460-09-7

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