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CS-W001157 4
Total: USD 88.00

2-Phenylpropionic acid

  • CAS No. 492-37-5

  • Cat. No. CS-W016324
  • Purity≥98%
  • MDL No.MFCD00002650

*For research and further manufacturing use only, not for direct human use.

2-Phenylpropionic acid|CS-W016324

Structure of 492-37-5

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General Information

  • CAS No. 492-37-5
  • Cat. No. CS-W016324
  • Purity ≥98%
  • MDL No. MFCD00002650
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₂
  • Molecular Weight 150.18
  • Synonym(s) None
  • SMILES C1=C(C(C(O)=O)C)C=CC=C1

Description

2-Phenylpropionic acid is a chiral carboxylic acid featuring a phenyl group attached to a prochiral methine carbon. This structural motif imparts enhanced metabolic stability and lipophilicity, making it valuable in medicinal chemistry for designing bioactive compounds and peptide mimetics.

Application

2-Phenylpropionic acid serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive compounds through established functional group transformations. Its α-chiral center and carboxylic acid functionality facilitate derivatization via amidation, esterification, and decarboxylation protocols. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in scalable synthetic routes for pharmaceutical intermediates and heterocyclic scaffolds.

Synthesis

  • Route1
    • null|null
      103-82-2
    • null|null
      74-88-4
    • ~92%
    • In-stock
      2-Phenylpropionic acid|CS-W016324
      492-37-5

    References

    • Azzena, Ugo; Dettori, Giovanna; Pisano, Luisa; Pittalis, Mario Tetrahedron, 2011 , vol. 67, # 19 p. 3470 - 3475
  • Route2
    • null|null
      124-38-9
    • null|null
      672-65-1
    • ~85%
    • In-stock
      2-Phenylpropionic acid|CS-W016324
      492-37-5

    References

    • Silvestri, Giuseppe; Gambino, Salvatore; Filardo, Giuseppe; Gulotta, Antonio Angewandte Chemie, 1984 , vol. 96, # 12 p. 978 - 979
  • Route3
    • null|null
      292638-84-7
    • null|null
      201230-82-2
    • ~10%
    • In-stock
      2-Phenylpropionic acid|CS-W016324
      492-37-5

    References

    • Council of Scientific and Industrial Research Patent: US6660883 B1, 2003 ; Location in patent: Page column 36-38 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.8747
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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