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CS-W001157 4
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2-Bromo-1-methyl-1H-benzo[d]imidazole

  • CAS No. 49572-60-3

  • Cat. No. CS-0063894
  • Molecule weight211.06
  • Purity≥97%
  • MDL No.MFCD00839528

*For research and further manufacturing use only, not for direct human use.

2-Bromo-1-methyl-1H-benzo[d]imidazole|CS-0063894

Structure of 49572-60-3

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General Information

  • CAS No. 49572-60-3
  • Cat. No. CS-0063894
  • Purity ≥97%
  • MDL No. MFCD00839528
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂
  • Molecular Weight 211.06
  • Synonym(s) 2-Bromo-1-methyl-1H-benzoimidazole
  • SMILES CN1C2=CC=CC=C2N=C1Br

Description

N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester) is a PEG linker that can easily react with activated NHS esters or carboxylic acid in the presence of EDC or HATU. The t-butyl group can be deprotected under acidic conditions.

Synthesis

  • Route1
    • null|null
      77-78-1
    • In-stock
      2-Bromobenzimidazole|CS-B1157
      54624-57-6
    • ~77%
    • In-stock
      2-Bromo-1-methyl-1H-benzo[d]imidazole|CS-0063894
      49572-60-3

    References

    • Costanzo, Michael J.; Almond Jr., Harold R.; Hecker, Leonard R.; Schott, Mary R.; Yabut, Stephen C.; Zhang, Han-Cheng; Andrade-Gordon, Patricia; Corcoran, Thomas W.; Giardino, Edward C.; Kauffman, Jack A.; Lewis, Joan M.; De Garavilla, Lawrence; Haertlein, Barbara J.; Maryanoff, Bruce E. Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1984 - 2008
  • Route2
    • In-stock
      2-Bromobenzimidazole|CS-B1157
      54624-57-6
    • null|null
      74-88-4
    • ~98%
    • In-stock
      2-Bromo-1-methyl-1H-benzo[d]imidazole|CS-0063894
      49572-60-3

    References

    • Zornik, Denise; Meudtner, Robert M.; Ela Malah, Tamer; Thiele, Christina M.; Hecht, Stefan Chemistry - A European Journal, 2011 , vol. 17, # 5 p. 1473 - 1484
  • Route3
    • null|null
      53114-86-6
    • ~64%
    • In-stock
      2-Bromo-1-methyl-1H-benzo[d]imidazole|CS-0063894
      49572-60-3

    References

    • Kolodyazhnaya, S. N.; Divaeva, L. N.; Zheltikova, N. N.; Simonov, A. M. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 10 p. 1090 - 1094 Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 10 p. 1360 - 1364

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.3358
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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