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CS-W001157 4
Total: USD 88.00

(2Z)-2-Methyl-2-butenedioic acid

  • CAS No. 498-23-7

  • Cat. No. CS-0059543
  • Purity≥97%
  • MDL No.MFCD00078086

*For research and further manufacturing use only, not for direct human use.

(2Z)-2-Methyl-2-butenedioic acid|CS-0059543

Structure of 498-23-7

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General Information

  • CAS No. 498-23-7
  • Cat. No. CS-0059543
  • Purity ≥97%
  • MDL No. MFCD00078086
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆O₄
  • Molecular Weight 130.10
  • Synonym(s) Methylmaleic acid; Citraconate
  • SMILES O=C(O)/C(C)=C\C(O)=O

Description

DMT-2O-Methyl-rG(ib) Phosphoramidite belongs to the group of 2O-Methyl RNA Phosphoramidites. 2O-Methyl RNA monomers are compatible with fast deprotection schemes that are based on the application of aliphatic amines, such as methylamine. 2O-Methyl RNA is a nucleic acid analog that is characterized by the exceptional hybridization properties that it imparts with complementary DNA or RNA, as well as increased stability against enzymatic degradation compared to natural nucleic acids. 2O-Methyl RNA monomers feature methoxy groups at the 2-position. The methoxy groups are perfectly stable in all conditions employed in the assembly of oligonucleotides by automated phosphoramidite synthesis, and in all standard alkaline deprotection conditions.DMT-2O-Methyl-rG(ib) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.It has widespread applications in the fields of: Diagnostic probesAptamer and ribozyme developmentMixed 2O-Methyl-RNA/DNA antisense molecules

Synthesis

  • Route1

    References

    • Biilmann Recueil des Travaux Chimiques des Pays-Bas, 1917 , vol. 36, p. 319 Recueil des Travaux Chimiques des Pays-Bas, 1918 , vol. 37, p. 246
  • Route2

    References

    • LUCITE INTERNATIONAL UK LIMITED; EASTHAM, Graham Ronald; JOHNSON, David William; WAUGH, Mark Patent: WO2013/160703 A1, 2013 ;
  • Route3

    References

    • LUCITE INTERNATIONAL UK LIMITED; Johnson, David William; Eastham, Graham Ronald; Poliakoff, Martyn; Huddle, Thomas Andrew Patent: US2013/303713 A1, 2013 ; Location in patent: Paragraph 0118-0128 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   0.1019
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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