4-Chloro-2-methylpyrimidine

Name: 4-Chloro-2-methylpyrimidine
Brand: ChemScene
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CAS No. 4994-86-9
Cat. No. CS-W009237
Purity≥95%
MDL No.MFCD00234069

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

4-Chloro-2-methylpyrimidine is a bench-stable heterocyclic building block featuring a chloro group at the 4-position and a methyl substituent at the 2-position. This electronic configuration enables efficient coupling reactions, particularly in palladium-catalyzed cross-couplings. The compound serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals due to its reactivity profile and compatibility with diverse functional groups.

Application

4-Chloro-2-methylpyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of pyrimidine-based scaffolds. Its chloro group at the C4 position facilitates nucleophilic substitution reactions with amines, thiols, and alkoxides, while the methyl group at C2 provides steric and electronic modulation. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating straightforward purification and integration into complex molecular architectures.

General Information

CAS No. 4994-86-9
Cat. No. CS-W009237
Purity ≥95%
MDL No. MFCD00234069
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂
Molecular Weight 128.56
Synonym(s) NSC 165514; Pyrimidine, 4-chloro-2-methyl- (7CI,8CI,9CI)
SMILES CC1=NC=CC(Cl)=N1

Computational Chemistry Data

TPSA 25.78
LogP 1.43842
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4-Chloro-2-methylpyrimidine

CAS No. 4994-86-9

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