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Structure of 500011-86-9
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This pyrazole-based scaffold integrates a bromine electrophile and a chloropyridine moiety, enabling direct coupling in cross-coupling reactions. The carboxylic acid group provides a handle for derivatization or conjugation, while the electron-deficient pyridine enhances reactivity. Bench-stable and moisture-tolerant, this compound serves as a key building block in medicinal chemistry and agrochemical synthesis.
3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid serves as a versatile building block for the synthesis of functionalized heterocyclic scaffolds. Its dual halogenation (Br at C3, Cl at pyridine C3) enables sequential cross-coupling reactions under palladium catalysis. The carboxylic acid group facilitates direct derivatization or incorporation into peptide-like linkages, offering orthogonal reactivity in multi-step synthesis. Bench-stable and amenable to standard purification methods, it functions effectively in medicinal chemistry campaigns targeting kinase inhibitors and other bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: