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CS-W001157 4
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Benzeneacetic acid, 2-fluoro-6-methoxy-

  • CAS No. 500912-19-6

  • Cat. No. CS-0031348
  • Purity≥90%
  • MDL No.MFCD00671770

*For research and further manufacturing use only, not for direct human use.

Benzeneacetic acid, 2-fluoro-6-methoxy-|CS-0031348

Structure of 500912-19-6

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General Information

  • CAS No. 500912-19-6
  • Cat. No. CS-0031348
  • Purity ≥90%
  • MDL No. MFCD00671770
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₃
  • Molecular Weight 184.16
  • Synonym(s) 2-Methoxy-6 fluoro-phenylacetic acid
  • SMILES O=C(CC1=C(C=CC=C1F)OC)O

Description

2-Fluoro-6-methoxyphenylacetic acid features a strategically positioned fluorine and methoxy group that enhance metabolic stability and lipophilicity. This arylacetic acid serves as a key building block in the synthesis of bioactive molecules, particularly in pharmaceutical intermediates where electron-withdrawing and electron-donating effects are finely balanced.

Application

2-Fluoro-6-methoxyphenylacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive arylalkanoic acid derivatives. Its fluorinated aromatic core provides enhanced metabolic stability and modulated lipophilicity, while the carboxylic acid group facilitates direct coupling or derivatization. The methoxy substituent offers orthogonal reactivity and favorable electronic effects, making this scaffold valuable for optimizing pharmacokinetic properties in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.4614
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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