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CS-W001157 4
Total: USD 88.00

(5-Bromo-2-fluoropyridin-3-yl)boronic acid

  • CAS No. 501435-91-2

  • Cat. No. CS-W009509
  • Purity≥96%
  • MDL No.MFCD04039317
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(5-Bromo-2-fluoropyridin-3-yl)boronic acid|CS-W009509

Structure of 501435-91-2

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Description

This boronate moiety integrates seamlessly into Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under standard conditions. The electron-deficient pyridine ring enhances reactivity, while the ortho-halogen substitution pattern supports selective functionalization. Bench-stable and moisture-tolerant, it streamlines synthesis in medicinal chemistry and materials science applications.

Application

(5-Bromo-2-fluoropyridin-3-yl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The ortho-fluoro and bromo substituents provide complementary reactivity for sequential functionalization, while the boronic acid group offers excellent bench stability and compatibility with standard Suzuki-Miyaura coupling conditions. Its defined regiochemistry and predictable transformation profile make it ideal for targeted synthesis of pharmaceutical intermediates and agrochemical scaffolds.

General Information

  • CAS No. 501435-91-2
  • Cat. No. CS-W009509
  • Purity ≥96%
  • MDL No. MFCD04039317
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BBrFNO₂
  • Molecular Weight 219.80
  • Synonym(s) 5-Bromo-2-fluoropyridine-3-boronic acid
  • SMILES OB(C1=CC(Br)=CN=C1F)O

Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.337
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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