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CS-W001157 4
Total: USD 88.00

(R)-Difluorphos

  • CAS No. 503538-69-0

  • Cat. No. CS-0087695
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-Difluorphos|CS-0087695

Structure of 503538-69-0

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General Information

  • CAS No. 503538-69-0
  • Cat. No. CS-0087695
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₈H₂₄F₄O₄P₂
  • Molecular Weight 682.54
  • Synonym(s) None
  • SMILES FC(O1)(F)OC2=C1C(C3=C(OC(F)(F)O4)C4=CC=C3P(C5=CC=CC=C5)C6=CC=CC=C6)=C(P(C7=CC=CC=C7)C8=CC=CC=C8)C=C2

Description

(R)-Difluorphos is a bench-stable, electron-rich phosphine ligand featuring two fluorinated aryl groups that enhance its oxidative stability and modulate electronic properties. This configuration delivers high catalytic efficiency in palladium-catalyzed cross-coupling reactions, particularly under mild conditions. The stereochemical integrity of the (R) enantiomer ensures predictable performance in asymmetric transformations.

Application

(R)-Difluorphos serves as a highly effective chiral ligand in palladium-catalyzed asymmetric cross-coupling reactions, enabling high enantioselectivity in the formation of stereodefined biaryl and alkyl-aryl scaffolds. Its fluorinated backbone enhances oxidative stability and improves catalyst longevity, while maintaining excellent functional group tolerance and ease of purification. This ligand is particularly valuable for synthesizing chiral intermediates in pharmaceutical development and agrochemical research.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   7.513
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   7

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