(R)-Difluorphos

Name: (R)-Difluorphos
Brand: ChemScene
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CAS No. 503538-69-0
Cat. No. CS-0087695
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 503538-69-0

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Description

(R)-Difluorphos is a bench-stable, electron-rich phosphine ligand featuring two fluorinated aryl groups that enhance its oxidative stability and modulate electronic properties. This configuration delivers high catalytic efficiency in palladium-catalyzed cross-coupling reactions, particularly under mild conditions. The stereochemical integrity of the (R) enantiomer ensures predictable performance in asymmetric transformations.

Application

(R)-Difluorphos serves as a highly effective chiral ligand in palladium-catalyzed asymmetric cross-coupling reactions, enabling high enantioselectivity in the formation of stereodefined biaryl and alkyl-aryl scaffolds. Its fluorinated backbone enhances oxidative stability and improves catalyst longevity, while maintaining excellent functional group tolerance and ease of purification. This ligand is particularly valuable for synthesizing chiral intermediates in pharmaceutical development and agrochemical research.

General Information

CAS No. 503538-69-0
Cat. No. CS-0087695
Purity ≥97%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₈H₂₄F₄O₄P₂
Molecular Weight 682.54
Synonym(s) None
SMILES FC(O1)(F)OC2=C1C(C3=C(OC(F)(F)O4)C4=CC=C3P(C5=CC=CC=C5)C6=CC=CC=C6)=C(P(C7=CC=CC=C7)C8=CC=CC=C8)C=C2

Computational Chemistry Data

TPSA 36.92
LogP 7.513
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 7

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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(R)-Difluorphos

CAS No. 503538-69-0

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