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CS-W001157 4
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2-Thiobarbituric acid

  • CAS No. 504-17-6

  • Cat. No. CS-M1811
  • Molecule weight144.15
  • Purity≥98%
  • MDL No.MFCD00006674

*For research and further manufacturing use only, not for direct human use.

2-Thiobarbituric acid|CS-M1811

Structure of 504-17-6

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General Information

  • CAS No. 504-17-6
  • Cat. No. CS-M1811
  • Purity ≥98%
  • MDL No. MFCD00006674
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄N₂O₂S
  • Molecular Weight 144.15
  • Synonym(s) 4,6-Dihydroxy-2-mercaptopyrimidine
  • SMILES S=C(NC(C1)=O)NC1=O

Description

Thiolactam ring formation via sulfur incorporation drives nucleophilic adduct generation in lipid peroxidation assays, a property exploited by 2-Thiobarbituric acid (CAS 504-17-6) to quantify malondialdehyde levels in oxidative stress studies.

Application

2-Thiobarbituric acid (CAS 504-17-6) quantifies malondialdehyde (MDA) in lipid peroxidation assays through a robust colorimetric reaction that forms a stable pink adduct under acidic conditions. This method is widely adopted for oxidative stress assessment. Researchers rely on this setup to evaluate membrane damage in biological samples with high sensitivity and reproducibility.

Synthesis

  • Route1
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      17356-08-0
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      105-53-3
    • ~72%
    • In-stock
      2-Thiobarbituric acid|CS-M1811
      504-17-6

    References

    • Medicinal Chemistry Research, , vol. 22, # 9 p. 4075 - 4086
  • Route2
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      996-82-7
    • null|null
      17356-08-0
    • ~%
    • In-stock
      2-Thiobarbituric acid|CS-M1811
      504-17-6

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. <2> 35, p. 456 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 49, p. 38
  • Route3
    • null|null
      17356-08-0
    • In-stock
      Dimethyl malonate|CS-0019394
      108-59-8
    • ~%
    • In-stock
      2-Thiobarbituric acid|CS-M1811
      504-17-6

    References

    • Canadian Journal of Chemistry, , vol. 64, p. 2087 - 2093

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.2
  • LogP   -1.0926
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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