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Structure of 50478-16-5
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5-Chlorothiophene-2-carbonitrile features a thiophene core with complementary electron-withdrawing chloro and nitrile groups at the 5- and 2-positions, respectively. This arrangement enhances electrophilicity at the ring system, enabling efficient coupling in cross-coupling reactions. The molecule exhibits bench-stable handling and good solubility in common organic solvents, facilitating integration into synthetic sequences for pharmaceuticals and functional materials.
5-Chlorothiophene-2-carbonitrile serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized thiophene scaffolds. Its dual electrophilic sites—chlorine at C5 and nitrile at C2—facilitate sequential coupling reactions via palladium-catalyzed cross-coupling or nucleophilic substitution. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, supporting rapid diversification of heterocyclic architectures in API development and organic semiconductor design.
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GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H310+H330-H318
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Precautionary Statements : P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: