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Structure of 50921-39-6
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This cyclobutane carboxylic acid features a para-chlorophenyl substituent, delivering enhanced lipophilicity and metabolic stability. The rigid cyclobutane scaffold imparts conformational constraint, ideal for probing receptor binding pockets in medicinal chemistry. Bench-stable and compatible with standard synthetic workflows.
1-(4-Chlorophenyl)cyclobutane-1-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard functional group transformations. Its cyclobutane core provides conformational rigidity, while the para-chlorophenyl and carboxylic acid groups offer orthogonal reactivity for derivatization, amide coupling, and metal-catalyzed cross-couplings. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: