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Structure of 51-21-8
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Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt Outperforms HOAt in sterically demanding peptide bond formations Compatible with carbodiimide-mediated; solution and solid phase peptide coupling; Less epimerization than HOBt in fragment condensation reactions K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character K-salt has a higher melting point than OxymaPure
5-Fluorouracil serves as a cornerstone pyrimidine analog in medicinal chemistry, enabling targeted incorporation into RNA and DNA via thymidylate synthase inhibition. Its fluorine substitution enhances metabolic stability and reactivity in nucleoside synthesis, facilitating the construction of antitumor prodrugs and heterocyclic scaffolds. Bench-stable and compatible with standard coupling protocols, it functions reliably in solid-phase oligonucleotide synthesis and kinase inhibitor derivatization workflows.
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GHS Pictogram :
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GHS No : GHS06,GHS08
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H351
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Precautionary Statements : P264-P270-P280-P330-P405-P501
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Lot numbers can be found on the outside label of a product: