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CS-W001157 4
Total: USD 88.00

5-Fluorouracil

  • CAS No. 51-21-8

  • Cat. No. CS-0993
  • Purity≥98%
  • MDL No.MFCD00006018
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Fluorouracil|CS-0993

Structure of 51-21-8

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Description

Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt Outperforms HOAt in sterically demanding peptide bond formations Compatible with carbodiimide-mediated; solution and solid phase peptide coupling; Less epimerization than HOBt in fragment condensation reactions K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character K-salt has a higher melting point than OxymaPure

Application

5-Fluorouracil serves as a cornerstone pyrimidine analog in medicinal chemistry, enabling targeted incorporation into RNA and DNA via thymidylate synthase inhibition. Its fluorine substitution enhances metabolic stability and reactivity in nucleoside synthesis, facilitating the construction of antitumor prodrugs and heterocyclic scaffolds. Bench-stable and compatible with standard coupling protocols, it functions reliably in solid-phase oligonucleotide synthesis and kinase inhibitor derivatization workflows.

General Information

  • CAS No. 51-21-8
  • Cat. No. CS-0993
  • Purity ≥98%
  • MDL No. MFCD00006018
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃FN₂O₂
  • Molecular Weight 130.08
  • Synonym(s) 5-FU
  • SMILES O=C(N1)NC=C(F)C1=O

Computational Chemistry Data

  • TPSA   65.72
  • LogP   -0.7977
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H351
Precautionary Statements : P264-P270-P280-P330-P405-P501

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