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CS-W001157 4
Total: USD 88.00

N-(4-Methoxyphenyl)acetamide

  • CAS No. 51-66-1

  • Cat. No. CS-0072050
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-(4-Methoxyphenyl)acetamide|CS-0072050

Structure of 51-66-1

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General Information

  • CAS No. 51-66-1
  • Cat. No. CS-0072050
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂
  • Molecular Weight 165.19
  • Synonym(s) p-Acetanasidine-N-(Methoxyphenyl)acetamide
  • SMILES O=C(C)NC1=CC=C(OC)C=C1

Description

N-(4-Methoxyphenyl)acetamide is a bench-stable aromatic amide featuring a para-methoxy substituent that enhances solubility and electron-donating character. This compound integrates readily into synthetic routes requiring moderate polarity and thermal resilience, serving as a key intermediate in the development of functionalized pharmaceuticals and agrochemicals.

Application

N-(4-Methoxyphenyl)acetamide serves as a versatile aryl amide building block in medicinal chemistry and synthetic organic research. Its structure combines a stable aniline-derived amide with a methoxy-substituted phenyl ring, enabling predictable reactivity in coupling reactions and electrophilic substitutions. The compound exhibits excellent bench stability, simple purification via recrystallization, and tolerance to common functional groups, making it well-suited for use in multistep synthesis of pharmaceutical intermediates and heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • Srinivas; Reddy, E. Bolla; Das, Biswanath Synlett, 2002 , # 4 p. 625 - 627
  • Route2
    • 1-(4-Methoxyphenyl)ethan-1-one oxime|CS-1639313
      2475-92-5
    • ~99%
    • In-stock
      N-(4-Methoxyphenyl)acetamide|CS-0072050
      51-66-1

    References

    • Srivastava, Vishnu P.; Patel, Rajesh; Garima; Yadav, Lal Dhar S. Chemical Communications, 2010 , vol. 46, # 31 p. 5808 - 5810
  • Route3
    • null|null
      104-94-9
    • null|null
      64-19-7
    • ~98%
    • In-stock
      N-(4-Methoxyphenyl)acetamide|CS-0072050
      51-66-1

    References

    • Brahmachari; Laskar; Sarkar Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 9 p. 1274 - 1281

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.6536
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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