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Structure of 51012-64-7
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2-Bromo-1-(m-tolyl)ethanone is a brominated aryl ketone featuring a meta-tolyl group attached to a bromoacetophenone scaffold. This compound serves as a key intermediate in the synthesis of functionalized biaryls and heterocycles, offering high reactivity in palladium-catalyzed cross-coupling reactions. The electron-deficient carbonyl and adjacent bromine facilitate efficient C–C bond formation under mild conditions.
2-Bromo-1-(m-tolyl)ethanone serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted benzyl motifs and heterocyclic scaffolds. Its bromine atom facilitates palladium-catalyzed cross-coupling reactions, while the ketone group supports nucleophilic additions and enolate chemistry. The m-tolyl substituent provides steric and electronic modulation, enhancing compatibility with diverse reaction conditions. This compound exhibits bench stability and is readily purified by recrystallization or flash chromatography, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: