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Structure of 512197-92-1
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2-Ethynyl-6-methoxypyridine features a conjugated alkyne tethered to a pyridine ring bearing a methoxy group, enabling efficient coupling in transition-metal-catalyzed reactions. The electron-rich pyridine core enhances reactivity in cross-coupling processes, while the pendant alkyne facilitates downstream functionalization via click chemistry or Sonogashira protocols. This scaffold offers robust stability under standard handling conditions and integrates seamlessly into complex molecular architectures.
2-Ethynyl-6-methoxypyridine serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to substituted pyridine scaffolds. Its ethynyl group exhibits high reactivity in Sonogashira and Glaser couplings, while the methoxy substituent provides moderate electron-donating character and enhances solubility. The compound demonstrates excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: