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Structure of 51227-28-2
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4-Methylnicotinaldehyde is a bench-stable, electron-deficient aldehyde featuring a pyridine ring with a methyl group at the 4-position. This configuration enhances its reactivity in nucleophilic addition and coupling reactions, particularly in the synthesis of heterocyclic scaffolds and bioactive compounds. The para-methyl substitution improves solubility in organic media while maintaining thermal stability under standard conditions.
4-Methylnicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient synthesis of pyridine-based scaffolds through standard condensation and coupling reactions. Its aldehyde functionality exhibits excellent compatibility with diverse functional groups, facilitating straightforward derivatization for drug discovery applications. The methyl substituent enhances metabolic stability and modulates electronic properties, offering favorable physicochemical profiles. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multistep syntheses and scale-up processes.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P261-P280-P304+P340-P405-P501
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Lot numbers can be found on the outside label of a product: