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CS-W001157 4
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2-Chlorothiazole-5-carbonitrile

  • CAS No. 51640-36-9

  • Cat. No. CS-W014401
  • Purity≥96%
  • MDL No.MFCD03012290
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chlorothiazole-5-carbonitrile|CS-W014401

Structure of 51640-36-9

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Description

2-Chlorothiazole-5-carbonitrile features a chlorinated thiazole core fused with a nitrile group, offering enhanced reactivity for heterocyclic synthesis. This bench-stable, moisture-tolerant compound integrates readily into pharmaceutical intermediates and functional materials via nucleophilic substitution or metal-catalyzed coupling.

Application

2-Chlorothiazole-5-carbonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the thiazole core via nucleophilic substitution or cross-coupling reactions. Its dual reactive sites—electrophilic chlorine and electron-deficient nitrile—facilitate modular synthesis of substituted thiazoles and heterocyclic scaffolds. The compound exhibits good bench stability and compatibility with standard reaction conditions, supporting efficient purification and scalability in API intermediate development.

General Information

  • CAS No. 51640-36-9
  • Cat. No. CS-W014401
  • Purity ≥96%
  • MDL No. MFCD03012290
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄HClN₂S
  • Molecular Weight 144.58
  • Synonym(s) 2-CHLOROTHIAZOLE-5-CARBONITRILE,2-CHLORO-5-THIAZOLE CARBONITRILE
  • SMILES ClC1=NC=C(S1)C#N

Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.66818
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

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