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Structure of 51767-39-6
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N-(4-Hydroxyphenyl)methanesulfonamide features a phenolic hydroxyl group conjugated to an electron-deficient sulfonamide, enabling hydrogen bonding and enhanced solubility. This scaffold integrates readily into bioactive molecules, serving as a stable pharmacophore in kinase inhibitor design and drug metabolism studies.
N-(4-Hydroxyphenyl)methanesulfonamide serves as a versatile building block in medicinal chemistry, enabling the introduction of both phenolic and sulfonamide functionalities in a single scaffold. Its hydroxyl group facilitates further derivatization via etherification or glucuronidation pathways, while the methanesulfonamide moiety provides metabolic stability and hydrogen-bonding capacity. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, making it suitable for modular synthesis of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H332-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: