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CS-W001157 4
Total: USD 88.00

4-(Pyrrolidin-1-yl)benzaldehyde

  • CAS No. 51980-54-2

  • Cat. No. CS-W017443
  • Purity≥97%
  • MDL No.MFCD00015469

*For research and further manufacturing use only, not for direct human use.

4-(Pyrrolidin-1-yl)benzaldehyde|CS-W017443

Structure of 51980-54-2

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General Information

  • CAS No. 51980-54-2
  • Cat. No. CS-W017443
  • Purity ≥97%
  • MDL No. MFCD00015469
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃NO
  • Molecular Weight 175.23
  • Synonym(s) 4-(1-Pyrrolidinyl)-benzaldehyde
  • SMILES O=CC1=CC=C(N2CCCC2)C=C1

Description

4-(Pyrrolidin-1-yl)benzaldehyde features a pyrrolidinyl group conjugated to an aromatic aldehyde, enabling efficient coupling in transition-metal-catalyzed transformations. This electron-rich scaffold integrates readily into pharmaceutical intermediates and functional materials, offering enhanced solubility and reactivity under standard conditions.

Application

4-(Pyrrolidin-1-yl)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to diverse heterocyclic scaffolds through nucleophilic addition and condensation reactions. The pyrrolidinyl group enhances solubility and modulates electronic properties, while the aldehyde functionality facilitates straightforward derivatization via reductive amination, Schiff base formation, or Ugi-type coupling. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis workflows.

Synthesis

  • Route1
    • null|null
      123-75-1
    • In-stock
      4-Bromobenzaldehyde|CS-W001138
      1122-91-4
    • ~67%
    • In-stock
      4-(Pyrrolidin-1-yl)benzaldehyde|CS-W017443
      51980-54-2

    References

    • Journal of Medicinal Chemistry, , vol. 51, # 5 p. 1333 - 1343
  • Route2
    • null|null
      123-75-1
    • p-Fluorobenzenecarboxaldehyde Atorvastatin calcium|CS-0214005
      459-57-4
    • ~93%
    • In-stock
      4-(Pyrrolidin-1-yl)benzaldehyde|CS-W017443
      51980-54-2

    References

    • Tetrahedron, , vol. 57, # 22 p. 4781 - 4785
  • Route3
    • In-stock
      1-Phenylpyrrolidine|CS-0156106
      4096-21-3
    • null|null
      68-12-2
    • ~92%
    • In-stock
      4-(Pyrrolidin-1-yl)benzaldehyde|CS-W017443
      51980-54-2

    References

    • Organic Preparations and Procedures International, , vol. 30, # 4 p. 455 - 460

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   2.0993
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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