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Structure of 52074-49-4
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2,6-Dichloro-4-fluoropyridine features a highly reactive pyridine core functionalized with chlorine and fluorine substituents at electron-deficient positions. This configuration enables efficient coupling in cross-coupling reactions, particularly in palladium-catalyzed processes. The molecule exhibits enhanced stability under standard bench conditions and integrates readily into complex heterocyclic architectures.
2,6-Dichloro-4-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization via nucleophilic substitution. Its orthogonal halogen reactivity facilitates sequential coupling reactions, particularly with amines and thiols, under mild conditions. The molecule exhibits excellent bench stability and compatibility with common protecting groups, making it well-suited for the synthesis of heterocyclic scaffolds and API intermediates in industrial R&D workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: