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Structure of 52107-66-1
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3-Iodo-2-methylbenzonitrile features a sterically hindered aryl iodide paired with an electron-deficient nitrile group, enabling efficient cross-coupling under standard conditions. The ortho-methyl substituent enhances stability and directs regioselective functionalization, while the iodine handle facilitates palladium-catalyzed transformations. This bench-stable intermediate integrates readily into complex molecular architectures.
3-Iodo-2-methylbenzonitrile serves as a versatile building block in medicinal chemistry and cross-coupling synthesis. The iodide group enables reliable Suzuki, Stille, and Negishi coupling reactions, while the nitrile and methyl groups offer orthogonal functionalization potential. Bench-stable and readily purified by column chromatography, it facilitates efficient access to substituted biaryls and heterocyclic scaffolds common in drug discovery programs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: