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CS-W001157 4
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1-Methylcyclopentane-1-carboxylic acid

  • CAS No. 5217-05-0

  • Cat. No. CS-0135257
  • Molecule weight128.17
  • Purity≥95%
  • MDL No.MFCD08444320

*For research and further manufacturing use only, not for direct human use.

1-Methylcyclopentane-1-carboxylic acid|CS-0135257

Structure of 5217-05-0

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General Information

  • CAS No. 5217-05-0
  • Cat. No. CS-0135257
  • Purity ≥95%
  • MDL No. MFCD08444320
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₂O₂
  • Molecular Weight 128.17
  • Synonym(s) 1-Methylcyclopentanecarboxylic acid
  • SMILES O=C(O)C1(CCCC1)C

Description

1-Methylcyclopentane-1-carboxylic acid features a rigid cyclopentane core with a carboxylic acid group at the quaternary carbon, delivering enhanced steric and electronic stability. This structural motif enables direct incorporation into bioactive scaffolds and serves as a robust building block for medicinal chemistry campaigns requiring constrained, lipophilic motifs under standard conditions.

Application

1-Methylcyclopentane-1-carboxylic acid serves as a versatile building block in medicinal and synthetic chemistry, offering a rigid, sterically defined cyclopentane scaffold with a carboxylic acid functional group. Its bench-stable nature and compatibility with standard coupling reactions enable efficient incorporation into peptide mimetics, macrocyclic compounds, and bioactive molecule frameworks. The α-methyl substitution enhances metabolic stability and modulates lipophilicity, making it valuable for structure–activity optimization in drug discovery.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.6513
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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