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Structure of 52353-35-2
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4-Chloro-2-(trifluoromethyl)quinazoline features a rigid, electron-deficient quinazoline core enhanced by a strongly inductive trifluoromethyl group and a chlorine substituent at the 4-position. This combination imparts high stability and tailored reactivity, enabling efficient incorporation into pharmaceutical scaffolds and advanced materials. The molecule's planar structure supports strong π-stacking interactions, facilitating precise molecular recognition in target binding.
4-Chloro-2-(trifluoromethyl)quinazoline serves as a versatile building block in medicinal chemistry, enabling efficient access to kinase inhibitors and bioactive heterocycles. Its electron-deficient quinazoline core facilitates palladium-catalyzed cross-coupling reactions, while the chloro and trifluoromethyl groups offer orthogonal reactivity for sequential functionalization. Bench-stable and compatible with standard synthetic workflows, it functions as a key scaffold in the development of targeted therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: