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Structure of 52418-50-5
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4,4-Dimethylpent-2-ynoic acid features a terminal alkyne group flanked by a sterically hindered dimethyl-substituted carbon chain, enhancing stability and reducing unwanted side reactions. This structural rigidity facilitates selective coupling in synthetic transformations, particularly in Sonogashira cross-coupling protocols. The carboxylic acid moiety enables direct derivatization or activation for peptide and polymer conjugation.
4,4-Dimethylpent-2-ynoic acid serves as a versatile building block in synthetic organic chemistry, enabling efficient access to α,β-unsaturated carboxylic acids and alkynylated heterocycles. Its terminal alkyne functionality facilitates palladium-catalyzed coupling reactions, while the sterically hindered gem-dimethyl group enhances stability and simplifies purification. The molecule functions reliably in standard transformations including esterification, amidation, and metalation, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: