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3-Chloro-4-(pyridin-2-ylmethoxy)aniline Neratinib Impurity

  • CAS No. 524955-09-7

  • Cat. No. CS-0204126
  • Purity≥98%
  • MDL No.MFCD08699389

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-(pyridin-2-ylmethoxy)aniline Neratinib Impurity|CS-0204126

Structure of 524955-09-7

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General Information

  • CAS No. 524955-09-7
  • Cat. No. CS-0204126
  • Purity ≥98%
  • MDL No. MFCD08699389
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₁ClN₂O
  • Molecular Weight 234.68
  • Synonym(s) 3-chloro-4-(2-pyridinylMethoxy)- BenzenaMine
  • SMILES NC1=CC=C(OCC2=NC=CC=C2)C(Cl)=C1

Synthesis

  • Route1

    References

    • WYETH Patent: US2006/270668 A1, 2006 ; Location in patent: Page/Page column 16-17 ;
  • Route2

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2006/64196 A1, 2006 ; Location in patent: Page/Page column 97 ; WO 2006/064196 A1
  • Route3

    References

    • Gavai, Ashvinikumar V.; Han, Wen-Ching; Chen, Ping; Ruediger, Edward H.; Mastalerz, Harold; Fink, Brian E.; Norris, Derek J. Patent: US2005/197339 A1, 2005 ; Location in patent: Page/Page column 12 ; US 20050197339 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   2.8962
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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