2-Chloro-3-methoxypyridine

Name: 2-Chloro-3-methoxypyridine
Brand: ChemScene
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CAS No. 52605-96-6
Cat. No. CS-W003068
Purity≥96%
MDL No.MFCD03426022

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

2-Chloro-3-methoxypyridine features a pyridine core with orthogonal chlorine and methoxy substituents, enabling selective functionalization in heterocyclic synthesis. This bench-stable, moisture-tolerant building block integrates readily into pharmaceutical intermediates and agrochemical scaffolds via cross-coupling or nucleophilic substitution reactions.

Application

2-Chloro-3-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the C2 position. The methoxy group at C3 provides orthogonal functionality for selective transformations, while the chloropyridine moiety offers excellent bench stability and compatibility with standard synthetic workflows. This compound facilitates efficient construction of heterocyclic scaffolds commonly found in pharmaceutical development.

General Information

CAS No. 52605-96-6
Cat. No. CS-W003068
Purity ≥96%
MDL No. MFCD03426022
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆ClNO
Molecular Weight 143.57
Synonym(s) None
SMILES COc1cccnc1Cl

Computational Chemistry Data

TPSA 22.12
LogP 1.7436
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-3-methoxypyridine

CAS No. 52605-96-6

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