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Structure of 52683-81-5
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(S)-4,4-Difluoropyrrolidine-2-carboxylic acid features a rigid pyrrolidine core with two fluorine atoms at the C4 position, conferring enhanced metabolic stability and altered electronic properties. This stereodefined building block integrates readily into peptidomimetics and bioactive compounds, offering improved membrane permeability and resistance to enzymatic degradation in medicinal chemistry applications.
(S)-4,4-Difluoropyrrolidine-2-carboxylic acid serves as a conformationally constrained, bioisosteric surrogate for proline in peptide-based drug discovery. Its difluorinated pyrrolidine ring enhances metabolic stability and modulates backbone geometry, enabling improved target affinity and membrane permeability. The carboxylic acid functionality facilitates direct coupling in solid-phase synthesis, while the stereochemistry ensures predictable folding in cyclic peptides. This building block is bench-stable, readily purified by crystallization, and compatible with standard coupling protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: