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Structure of 52692-09-8
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4-Iodo-1-methoxy-2-nitrobenzene features a nitro group at the ortho position relative to the methoxy moiety, creating a strongly electron-deficient aromatic system. The iodine substituent enables facile cross-coupling reactions under palladium catalysis. This compound serves as a valuable intermediate in the synthesis of functionalized aryl scaffolds for pharmaceutical and materials applications.
4-Iodo-1-methoxy-2-nitrobenzene serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki and Stille reactions due to its stable iodine handle and orthogonal functionalization. The methoxy and nitro groups provide predictable electronic modulation and facilitate downstream transformations, including selective reduction and further functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for synthetic workflows targeting complex heterocycles and pharmaceutical intermediates.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: