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CS-W001157 4
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Dimethyl 2-fluoroterephthalate

  • CAS No. 5292-47-7

  • Cat. No. CS-0319889
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Dimethyl 2-fluoroterephthalate|CS-0319889

Structure of 5292-47-7

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General Information

  • CAS No. 5292-47-7
  • Cat. No. CS-0319889
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉FO₄
  • Molecular Weight 212.17
  • Synonym(s) dimethyl 2-fluorobenzene-1,4-dicarboxylate
  • SMILES COC(=O)C1=CC(=C(C=C1)C(=O)OC)F

Description

Dimethyl 2-fluoroterephthalate features a fluorinated aromatic core with two ester groups, enabling direct incorporation into polyesters and copolymers via melt or solution condensation. The para-fluoro substituent enhances electron-withdrawal and thermal stability, while the methyl ester handles facilitate efficient derivatization. This compound serves as a key monomer for high-performance polymers requiring controlled chain extension and enhanced rigidity.

Application

Dimethyl 2-fluoroterephthalate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to fluorinated aromatic scaffolds. Its dual ester functionality and ortho-fluoro substitution facilitate subsequent coupling reactions, including palladium-catalyzed cross-couplings and nucleophilic aromatic substitutions. The compound exhibits excellent bench stability and ease of purification, making it well-suited for use in medicinal chemistry and materials science applications requiring controlled introduction of fluorine and aromatic rigidity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   1.3989
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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