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Structure of 5330-63-2
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Tert-butyl (3-chlorophenyl)carbamate serves as a robust protecting group for primary amines, offering enhanced stability under basic conditions. The ortho-chlorinated aryl moiety imparts electron-withdrawing character, facilitating selective deprotection in polar environments. This derivative integrates cleanly into peptide synthesis workflows and maintains integrity during prolonged storage.
Tert-butyl (3-chlorophenyl)carbamate serves as a stable, bench-ready nitrogen protecting group for aniline derivatives. It facilitates selective N-alkylation and coupling reactions under mild conditions, with orthogonal deprotection compatibility in standard protocols. Its moderate steric bulk enhances regioselectivity in electrophilic aromatic substitution, while the chlorophenyl moiety enables further functionalization via cross-coupling. The compound exhibits excellent stability during storage and purification, making it ideal for iterative synthesis workflows in medicinal chemistry and API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P405-P501
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Lot numbers can be found on the outside label of a product: