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Structure of 5345-27-7
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3-(Methylsulfonyl)benzoic acid features a sulfonate group that enhances solubility and metabolic stability, while the carboxylic acid moiety enables direct conjugation or derivatization. This combination facilitates integration into bioconjugation workflows and drug discovery scaffolds requiring polar, robust functional handles.
3-(Methylsulfonyl)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of both a sulfonamide handle and a carboxylic acid for conjugation or derivatization. Its ortho-sulfonyl group enhances metabolic stability and modulates solubility, while the carboxylic acid facilitates amide coupling, esterification, or salt formation. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it well-suited for use in multi-step syntheses of bioactive molecules and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: