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Structure of 5385-52-4
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1-Fluoro-2-nitronaphthalene features a fluorine atom at the 1-position and a nitro group at the 2-position on a naphthalene core, creating a highly electron-deficient aromatic system. This strategic substitution enables efficient coupling in transition-metal-catalyzed reactions, particularly in cross-coupling and nucleophilic aromatic substitution processes. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it a reliable building block for advanced organic synthesis.
1-Fluoro-2-nitronaphthalene serves as a versatile building block in synthetic organic chemistry, enabling regioselective nucleophilic aromatic substitution (SNAr) reactions due to the strong electron-withdrawing effect of the nitro group ortho to fluorine. Its bench-stable nature and compatibility with diverse nucleophiles—such as amines, thiols, and alkoxides—facilitate efficient construction of functionalized naphthalene derivatives. This compound functions as a key intermediate in the synthesis of pharmaceutical scaffolds, agrochemicals, and advanced materials, offering predictable reactivity and straightforward purification.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: