3-Chloro-5-(trifluoromethyl)benzoic acid

Name: 3-Chloro-5-(trifluoromethyl)benzoic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 53985-49-2
Cat. No. CS-W003189
Purity≥96%
MDL No.MFCD04115846

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-(trifluoromethyl)benzoic acid|CS-W003189

Structure of 53985-49-2

Size

Price

Quantity

* Please select Quantity before adding items.

Description

3-Chloro-5-(trifluoromethyl)benzoic acid features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the ortho-chloro substituent provides steric and electronic modulation. This combination delivers robust functionality in medicinal chemistry applications, particularly as a building block for bioactive molecules requiring lipophilic character and resistance to oxidative degradation.

Application

3-Chloro-5-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient functionalization via standard carboxylic acid transformations. Its electron-withdrawing trifluoromethyl and chloro substituents enhance metabolic stability and modulate electronic properties, while the carboxylic acid group facilitates amide coupling, esterification, and salt formation. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for scalable synthesis workflows.

General Information

CAS No. 53985-49-2
Cat. No. CS-W003189
Purity ≥96%
MDL No. MFCD04115846
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄ClF₃O₂
Molecular Weight 224.56
Synonym(s) 3-Chloro-5-carboxybenzotrifluoride
SMILES ClC1=CC(C(O)=O)=CC(C(F)(F)F)=C1

Computational Chemistry Data

TPSA 37.3
LogP 3.057
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

3-Chloro-5-(trifluoromethyl)benzoic acid sigma3-Chloro-5-(trifluoromethyl)benzoic acid manufacturer3-Chloro-5-(trifluoromethyl)benzoic acid price3-Chloro-5-(trifluoromethyl)benzoic acid structure3-Chloro-5-(trifluoromethyl)benzoic acid SDSbuy 3-Chloro-5-(trifluoromethyl)benzoic acid3-Chloro-5-(trifluoromethyl)benzoic acid supplier3-Chloro-5-(trifluoromethyl)benzoic acid uses3-Chloro-5-(trifluoromethyl)benzoic acid molecular weightprice of 3-Chloro-5-(trifluoromethyl)benzoic acid3-Chloro-5-(trifluoromethyl)benzoic acid chemical name formula of 3-Chloro-5-(trifluoromethyl)benzoic acid

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3-Chloro-5-(trifluoromethyl)benzoic acid

CAS No. 53985-49-2

Recommended Products