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Structure of 54-77-3
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Inducing cholinergic receptor agonism through irreversible binding, 1,1-Dimethyl-4-phenylpiperazinium iodide (CAS 54-77-3) functions as a potent neurochemical probe in synaptic transmission studies and facilitates sulfonamide derivatization in medicinal chemistry workflows.
1,1-Dimethyl-4-phenylpiperazinium iodide (CAS 54-77-3) activates non-selective nicotinic acetylcholine receptors to probe α7 and α4β2 subtypes in cardiovascular autonomic control within urethane-anesthetized mice. It enhances glucose tolerance in diet-induced obese models. Researchers exploit this to dissect enteric neuron signaling in guinea-pig colon, revealing key pathways in gut motility regulation.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: