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CS-W001157 4
Total: USD 88.00

1,1-Dimethyl-4-phenylpiperazinium iodide

  • CAS No. 54-77-3

  • Cat. No. CS-W009906
  • Purity≥98%
  • MDL No.MFCD00011976
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1,1-Dimethyl-4-phenylpiperazinium iodide|CS-W009906

Structure of 54-77-3

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Description

Inducing cholinergic receptor agonism through irreversible binding, 1,1-Dimethyl-4-phenylpiperazinium iodide (CAS 54-77-3) functions as a potent neurochemical probe in synaptic transmission studies and facilitates sulfonamide derivatization in medicinal chemistry workflows.

Application

1,1-Dimethyl-4-phenylpiperazinium iodide (CAS 54-77-3) activates non-selective nicotinic acetylcholine receptors to probe α7 and α4β2 subtypes in cardiovascular autonomic control within urethane-anesthetized mice. It enhances glucose tolerance in diet-induced obese models. Researchers exploit this to dissect enteric neuron signaling in guinea-pig colon, revealing key pathways in gut motility regulation.

General Information

  • CAS No. 54-77-3
  • Cat. No. CS-W009906
  • Purity ≥98%
  • MDL No. MFCD00011976
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉IN₂
  • Molecular Weight None
  • Synonym(s) 1,1-Dimethyl-4-phenylpiperazin-1-ium (iodide)
  • SMILES C[N+]1(C)CCN(C2=CC=CC=C2)CC1.[I-]

Computational Chemistry Data

  • TPSA   3.24
  • LogP   -1.413
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501

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