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Structure of 54045-74-8
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2-Bromo-1,3-thiazole-5-carboxylic acid methyl ester features a brominated thiazole core with a carboxylate ester handle, enabling direct functionalization in cross-coupling and heterocyclic elaboration. The electron-deficient ring facilitates nucleophilic substitution, while the methyl ester offers synthetic flexibility for downstream derivatization under standard conditions.
2-Bromo-1,3-thiazole-5-carboxylic acid methyl ester serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions for the construction of biologically relevant thiazole scaffolds. The bromo group facilitates efficient C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the ester functionality offers compatibility with a range of transformations including hydrolysis and nucleophilic substitution. Its bench-stable nature and predictable reactivity make it well-suited for iterative synthesis workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: