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Structure of 5405-40-3
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(S)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one is a chiral synthon featuring a stereogenic center at the C3 position and a hydroxyl group flanked by a geminal dimethyl substitution. This configuration imparts enhanced stability and predictable reactivity in asymmetric synthesis. The molecule integrates readily into complex frameworks through selective transformations at the carbonyl and hydroxyl functionalities. Its bench-stable nature facilitates handling under standard conditions.
(S)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one serves as a versatile chiral building block in medicinal chemistry, enabling stereoselective synthesis of bioactive molecules. Its constrained cyclic structure supports efficient functionalization at the C3 hydroxyl and C4 quaternary center, with demonstrated compatibility in standard coupling and oxidation reactions. Bench-stable and amenable to purification via chromatography or recrystallization, it functions effectively in multi-step syntheses of heterocyclic scaffolds and natural product analogs.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H318-H303
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: