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Structure of 5405-63-0
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This phosphonium phenolate features a hydroxyl group ortho to the phosphonium moiety, enabling facile deprotonation and enhanced nucleophilicity. The triphenylphosphine substituent imparts steric bulk and stabilizes the adjacent negative charge, facilitating use in polar solvents. Designed for synthetic applications requiring stable, reactive aryl anions under mild conditions.
4-Hydroxy-2-(triphenylphosphonio)phenolate serves as a versatile synthon in transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C bond formation at the ortho position of phenolic substrates. Its stable phosphonium functionality facilitates Stetter-type and Negishi-type couplings with high chemoselectivity, while the phenolate moiety provides enhanced solubility and compatibility with diverse reaction conditions. Ideal for bench-scale synthesis of functionalized biaryls and heterocyclic scaffolds, it offers predictable reactivity and straightforward purification.
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H411
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Precautionary Statements : P264-P270-P273-P301+P310-P330-P391-P501
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Lot numbers can be found on the outside label of a product: