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Structure of 5426-59-5
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6-Bromo-2-methylquinazolin-4(3H)-one is a heterocyclic scaffold featuring a bromine substituent at the 6-position and a methyl group at the 2-position, conferring enhanced electronic and steric properties. This core integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and bioactive small molecules, offering improved metabolic stability and favorable binding interactions in drug discovery pipelines.
6-Bromo-2-methylquinazolin-4(3H)-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position via palladium-catalyzed cross-coupling reactions. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient synthesis of quinazoline-based scaffolds relevant to kinase inhibitor development. The methyl group at C2 enhances metabolic stability, while the bromine substituent provides a reliable handle for further derivatization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: