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CS-W001157 4
Total: USD 88.00

Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one

  • CAS No. 54346-27-9

  • Cat. No. CS-W022939
  • Purity≥95%
  • MDL No.MFCD20617746
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one|CS-W022939

Structure of 54346-27-9

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Description

Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one delivers a rigid, electron-deficient heterocyclic scaffold ideal for bioactive compound design. This bench-stable core integrates readily into pharmaceutical intermediates, offering enhanced solubility and predictable reactivity in synthetic transformations.

Application

Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its fused ring system exhibits robust bench stability and tolerates diverse functional groups, facilitating downstream modifications via nucleophilic substitution or transition-metal-catalyzed coupling. The core structure functions as a privileged motif in kinase inhibitors and other pharmaceutical candidates, with predictable reactivity in standard synthetic protocols.

General Information

  • CAS No. 54346-27-9
  • Cat. No. CS-W022939
  • Purity ≥95%
  • MDL No. MFCD20617746
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₄O
  • Molecular Weight 136.11
  • Synonym(s) Pyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
  • SMILES O=C1NC=NC2=CC=NN21

Computational Chemistry Data

  • TPSA   63.05
  • LogP   -0.5824
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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