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CS-W001157 4
Total: USD 88.00

2,6-Dichloropurine

  • CAS No. 5451-40-1

  • Cat. No. CS-W007367
  • Purity≥97%
  • MDL No.MFCD00077725

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloropurine|CS-W007367

Structure of 5451-40-1

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General Information

  • CAS No. 5451-40-1
  • Cat. No. CS-W007367
  • Purity ≥97%
  • MDL No. MFCD00077725
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Cl₂N₄
  • Molecular Weight 189.00
  • Synonym(s) None
  • SMILES C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2

Application

2,6-Dichloropurine serves as a key building block in the synthesis of purine-based heterocycles, enabling efficient access to nucleoside analogs through standard coupling protocols. Its orthogonal reactivity allows selective functionalization at C-2 and C-6 positions, facilitating the construction of pharmaceutically relevant scaffolds. The compound exhibits excellent bench stability and compatibility with common purification methods, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Sun, Zhihua; Wang, Han; Wen, Kun; Li, Ya; Fan, Erkang Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 4149 - 4153
  • Route2
    • 2-Amino-6-chloropurine Clofarabine Impurity|CS-0229147
      10310-21-1
    • null|null
      110-46-3
    • ~%
    • In-stock
      2,6-Dichloropurine|CS-W007367
      5451-40-1

    References

    • US2003/144508 A1, ;
  • Route3
    • 2-Amino-6-chloropurine Clofarabine Impurity|CS-0229147
      10310-21-1
    • ~52%
    • In-stock
      2,6-Dichloropurine|CS-W007367
      5451-40-1

    References

    • Steklov, Mikhail Yu.; Tararov, Vitali I.; Romanov, Georgy A.; Mikhailov, Sergey N. Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 7-8 p. 503 - 511

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.46
  • LogP   1.6597
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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