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CS-W001157 4
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1H-Indole-3-carbonitrile

  • CAS No. 5457-28-3

  • Cat. No. CS-W007588
  • Purity≥96%
  • MDL No.MFCD00022717

*For research and further manufacturing use only, not for direct human use.

1H-Indole-3-carbonitrile|CS-W007588

Structure of 5457-28-3

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General Information

  • CAS No. 5457-28-3
  • Cat. No. CS-W007588
  • Purity ≥96%
  • MDL No. MFCD00022717
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆N₂
  • Molecular Weight 142.16
  • Synonym(s) 3-Cyanoindole
  • SMILES C1=CC=CC2=C1[NH]C=C2C#N

Description

Mal-Cyclohexyl-PEG3-Biotin is a PEG linker containing a maleimide moiety and a biotin group. Maleimides react specifically with sulfhydryl groups to form a stable thioether linkage when the pH is between 6.5 and 7.5. The biotinylation can react with amine molecules in the presence of activator EDC or HATU. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein. The PEG moiety also increases solubility of Biotin-PEG conjugates considerably.

Synthesis

  • Route1

    References

    • Capdevielle, Patrice; Lavigne, Andre; Maumy, Michel Synthesis, 1989 , # 6 p. 451 - 452
  • Route2

    References

    • Patil, Dipak; Dalal, Dipak Synthetic Communications, 2013 , vol. 43, # 1 p. 118 - 128
  • Route3
    • Indole, ≥99%|CS-1268948
      120-72-9
    • null|null
      68-12-2
    • ~82%
    • In-stock
      1H-Indole-3-carbonitrile|CS-W007588
      5457-28-3

    References

    • Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2012 , vol. 68, # 24 p. 4588 - 4595

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.58
  • LogP   2.03958
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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