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Structure of 5458-56-0
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This tetrahydroquinazoline derivative features a fused heterocyclic core with dual chloro substituents enhancing electron deficiency and metabolic stability. The carboxylic acid group enables direct conjugation or salt formation, facilitating solubility and integration into bioactive scaffolds. Designed for medicinal chemistry applications, it serves as a rigid, polarizable building block in kinase inhibitor and CNS-targeted compound development.
2,4-Dichloro-5,6,7,8-tetrahydroquinazoline-6-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its functionalized tetrahydroquinazoline core enables selective derivatization at the carboxylic acid and chlorine sites, facilitating downstream coupling reactions and structural diversification. The molecule exhibits good bench stability and compatibility with standard synthetic protocols, supporting efficient incorporation into bioactive scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: