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Structure of 54752-50-0
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7-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one features a sterically hindered trifluoromethyl group at the 7-position, enhancing electron deficiency across the aromatic ring system. This moiety integrates readily into synthetic scaffolds requiring strong electron-withdrawing character and improved metabolic stability. The dihydronaphthalene core provides a rigid, planar framework suitable for conjugated systems.
7-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functional group manipulations. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the dihydronaphthalenone core supports diverse transformations including hydrogenation, electrophilic substitution, and coupling reactions. Bench-stable and amenable to purification via chromatography or recrystallization, it functions as a reliable building block for drug discovery campaigns requiring modulated physicochemical properties.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: