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Structure of 549547-88-8
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5-Chloro-2-iodobenzonitrile features a chlorine substituent at the meta position and an iodine atom at the ortho position relative to the nitrile group, creating a sterically accessible, electron-deficient aryl halide platform. This configuration enables efficient coupling in palladium-catalyzed cross-coupling reactions, particularly Suzuki-Miyaura and Stille transformations, due to enhanced reactivity and stability under standard conditions.
5-Chloro-2-iodobenzonitrile serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling the construction of biaryl and heteroaryl scaffolds. The ortho-iodo group facilitates efficient palladium-catalyzed coupling, while the nitrile and chloro substituents provide orthogonal reactivity for downstream functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: