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CS-W001157 4
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Methyl 6-fluorobenzo[b]thiophene-2-carboxylate

  • CAS No. 550998-52-2

  • Cat. No. CS-0102226
  • Purity≥97%
  • MDL No.MFCD11044557
  • HazMat Fee +

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    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 6-fluorobenzo[b]thiophene-2-carboxylate|CS-0102226

Structure of 550998-52-2

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Description

Methyl 6-fluorobenzo[b]thiophene-2-carboxylate features a fluorinated benzo[b]thiophene core with a methyl ester at the 2-position, offering enhanced electron-withdrawing character and improved solubility in organic media. This scaffold serves as a key building block for bioactive heterocycles and pharmaceutical intermediates, particularly in kinase inhibitor development.

Application

Methyl 6-fluorobenzo[b]thiophene-2-carboxylate serves as a versatile building block in the synthesis of biologically active heterocycles, leveraging the electron-withdrawing fluorine substituent to modulate reactivity and metabolic stability. The ester functionality enables straightforward derivatization via hydrolysis or nucleophilic substitution, while the benzo[b]thiophene core provides a rigid, planar scaffold suitable for pharmaceutical and materials applications. Bench-stable and compatible with standard coupling reactions, it facilitates efficient access to advanced intermediates in medicinal chemistry and process development workflows.

General Information

  • CAS No. 550998-52-2
  • Cat. No. CS-0102226
  • Purity ≥97%
  • MDL No. MFCD11044557
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇FO₂S
  • Molecular Weight 210.22
  • Synonym(s) 6-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
  • SMILES O=C(C1=CC2=CC=C(F)C=C2S1)OC

Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.827
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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